Updated: Jul 6
Like dissolves like; the formula to remember when it comes to dissolve anything. Solubility of material depends many factors including its polarity. In general polar compounds dissolve in polar solvents. A common example is sugar in water. However cannabinoids, fat soluble compounds, sparingly soluble in water.
The advantage of water soluble cannabinoids like CBD and CBG relies on its application in water based products including cosmetics and beverages. The innovate formulation makes CBD readily soluble in water.
A method to dissolve CBD in water is to convert in to an emulsion. The surfactant or emulsifier acts as an agent between fat soluble cannabinoids and water to create a single phase aqueous layer. Oil in water (O/W) and water in oil (W/O) are the two types of emulsions. Emulsification is not a novel technology. It has been used in many industries. Milk, mayonnaise, ice cream and sauces are examples of food emulsions.
The initial step to prepare CBD emulsion is to find the required hydrophilic-lipophylic-balance (HLB)
of emulsifier or preferably mixture of emulsifiers. The total HLB value of the cannabinoids oil or isolate and other oil ingredients should be equalized with the HLB value of corresponding emulsifiers. There are various open assessable source of information regarding the HLB of commonly used oils and emulsifiers one to consider. However the HLB of cannabinoids oils and isolates need to be determined experimentally. It is vital to begin with selected food grade emulsifiers meeting the structural requirement of cannabinoids to be dissolved. Subsequently optimize the process by fine tuning the HLB for better solubility and stability. If cannabinoids emulsification process or products are of your interest, keep in touch with us here for free consultation.
A mechanical mixing is enough to get a quality emulsion. However there are various technologies used including in the pharmaceutical industry to generate nano emulsion and liposomes. A continues flow nano-emulsification procedure based on high intensity ultrasound has been reported. The following procedure demonstrate, in a laboratory set up for experimental purpose, the preparation of CBD nano-emulsion using ultrasound.
Ingredients list (% w/w)
CBD distillate = 5.4%
Refined Olive oil = 7.29%
Tween 20 = 3.7%
Span 80 = 0.8%
Water = 82.9%
All oily ingredients were mixed, heated to 50°C if necessary. To the oil phase a mixture of Tween 20 in water was added. The resulting mixture was stirred mechanically before it subject to sonication at 20 kHz and 90 um. The process continued for 30 minutes at below
60°C. Dynamic light scattering experiments proved the average droplet diameter size
is nearly equal to 100 nm. Which means the resulting translucent nano-emulsion is most likely be stable.
Direction of use of water soluble CBD drops:
Kanna Star water soluble CBD drops are prepared under strict quality control to meet our stringent product specification. We use high quality GAP grade industrial hemp to produce CBD distillates and isolates. Extended laboratory analysis of each batch ensures every product meets our quality requirements. The UK’s Food Safety Authorization (FSA) recommend 70 mg of CBD for maximum daily intake. That equals to 28 drops of a 5% Kanna Star water soluble CBD. We suggest to mix few CBD drops (4-6) with a glass of drinking water before its consumption.
1) J. drug. sci. tech., 60, 2000,101953